Module 1: Biology and Pathophysiology of Chronic Myelogenous Leukemia

This learning activity has been designated for 2.00 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in this activity.

Learning Objectives
After completing this educational activity, the learner should be better able to:

  • Explain the molecular anatomy of the BCR-ABL rearrangement associated with the presence of the Philadelphia (Ph) chromosome
  • Recognize the signal transduction pathways activated by constitutive BCR-ABL tyrosine kinase activity
  • Understand the molecular causes of disease progression resulting from the genetic instability characterizing Ph-positive chronic myelogenous leukemia
  • Describe the potential mechanisms responsible for the occurrence of the t(9;22) translocation and of the BCR-ABL rearrangement 

Target Audience
This learning activity is intended for medical oncologists, hematologists, stem cell transplant physicians, and other interested healthcare professionals who manage and treat chronic myelogenous leukemia in the hematology/oncology and transplant patient settings.

Release Date: November 30, 2008
Expiration date: November 30, 2009

 Click here to view Technical Requirements

 Click here to view How To Complete a Learning Module and Claim Credits

(*Please check this box to proceed - required)

Start the Module

About Us Contact Us Terms of Use Privacy Policy Technical Requirements Help