Learning Objectives
After completing this educational activity, the learner should be better able to:

• Explain the molecular anatomy of the BCR-ABL rearrangement associated with the presence of the Philadelphia (Ph) chromosome
• Recognize the signal transduction pathways activated by constitutive BCR-ABL tyrosine kinase activity
• Understand the molecular causes of disease progression resulting from the genetic instability characterizing Ph-positive chronic myelogenous leukemia
• Describe the potential mechanisms responsible for the occurrence of the t(9;22) translocation and of the BCR-ABL rearrangement 

Target Audience
This learning activity is intended for medical oncologists, hematologists, stem cell transplant physicians, and other interested healthcare professionals who manage and treat chronic myelogenous leukemia in the hematology/oncology and transplant patient settings.