Module 1: Biology and Pathophysiology of Chronic Myelogenous Leukemia
This learning activity has been designated for 2.00 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in this activity.
After completing this educational activity, the learner should be better able to:
Explain the molecular anatomy of the BCR-ABL rearrangement associated with the presence of the Philadelphia (Ph) chromosome
- Recognize the signal transduction pathways activated by constitutive BCR-ABL tyrosine kinase activity
- Understand the molecular causes of disease progression resulting from the genetic instability characterizing Ph-positive chronic myelogenous leukemia
Describe the potential mechanisms responsible for the occurrence of the t(9;22) translocation and of the BCR-ABL rearrangement
This learning activity is intended for medical oncologists, hematologists, stem cell transplant physicians, and other interested healthcare professionals who manage and treat chronic myelogenous leukemia in the hematology/oncology and transplant patient settings.
Release Date: November 30, 2008
Expiration date: November 30, 2009
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